Snap-8
Also known as Acetyl octapeptide-3, Ac-EEMQRRAD-NH2
Snap-8 (acetyl octapeptide-3) is a synthetic eight-amino-acid peptide modeled on the N-terminal region of the neuronal protein SNAP-25. It is studied in cosmetic research on expression wrinkles.
Preclinical research
Size
1 option- Catalog no.
- NP810
- Specification
- 10mg*10vials
- Per kit
- 10 vials
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
Snap-8 is an elongated analog of acetyl hexapeptide-3 (Argireline, Ac-EEMQRR-NH2), with two additional residues: Ac-EEMQRRAD-NH2. Argireline was rationally designed to mimic part of SNAP-25 and interfere with the SNARE complex that drives neurotransmitter release, an approach intended to reproduce, at much lower potency, one effect of botulinum toxin. Snap-8 was developed by the cosmetic ingredient industry along the same lines. Peer-reviewed data on Snap-8 alone are scarce; indexed human studies test it only within multi-ingredient formulations, so its individual contribution cannot be isolated.
Class: SNARE-modulating cosmetic peptide
Mechanism of action
How the compound acts, as described in the literature.
Designed to compete with SNAP-25 for a position in the SNARE complex, the protein assembly required for calcium-dependent vesicle fusion and acetylcholine release at nerve terminals.
The parent hexapeptide, Argireline, inhibited neurotransmitter release with a potency similar to botulinum toxin A but much lower efficacy; comparable mechanistic data for Snap-8 have not been published in indexed journals.
Reduced neurotransmitter release is proposed to lessen contraction of the facial muscles that form expression lines; this effect has not been isolated for Snap-8 in controlled human studies.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2024
Human cosmetic study
PMID 39082657Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.
Shin JY, et al. · Ann Dermatol
In 24 healthy subjects, a microneedle patch containing acetyl octapeptide-3, ascorbyl glucoside and cyclic lysophosphatidic acid improved eye-wrinkle, hydration and elasticity measures versus a hyaluronic acid patch; the peptide's individual effect was not assessed.
2020
Human cosmetic study
PMID 31134751Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
Avcil M, et al. · J Cosmet Dermatol
A 12-week single-center study of microneedle patches containing acetyl octapeptide-3 with other peptides, adenosine and seaweed extracts reported fewer fine lines and higher hydration and dermal density; the design did not isolate the peptide's effect.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
No peer-reviewed studies of Snap-8 alone are indexed; the two human studies tested multi-ingredient patches, were small, and did not report randomization, so the peptide's contribution is unknown. No adverse effects were reported in those studies, but long-term safety data are lacking. Snap-8 is a cosmetic ingredient, not an approved drug.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| NP810 | Snap-8 | 10mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.