DSIP
Also known as Delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
A nine-amino-acid peptide first isolated in 1977 from rabbit cerebral venous blood. It is studied for effects on sleep EEG patterns and neuroendocrine function, although its natural role and receptor remain unidentified.
Clinical-stage research
Size
3 options- Catalog no.
- DS5
- Specification
- 5mg*10vials
- Per kit
- 10 vials
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
Delta sleep-inducing peptide (DSIP), sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, was isolated by Schoenenberger and Monnier in Basel and named for its ability to enhance delta and spindle EEG activity in rabbits. Small human studies in the 1980s and early 1990s examined insomnia and chronic pain, with inconsistent results. Despite decades of study, no DSIP gene, precursor protein, or specific receptor has been identified, and a 2006 review described its status as a sleep factor as poorly documented. Later work has focused on possible neuroendocrine roles of DSIP-like peptides.
Class: Nonapeptide (putative sleep-related neuropeptide)
Mechanism of action
How the compound acts, as described in the literature.
Intraventricular infusion of synthetic DSIP in rabbits produced specific enhancement of delta and spindle EEG activity, whereas fragments and analogues tested in parallel did not (Schoenenberger 1977).
No dedicated gene, precursor, or receptor has been found. DSIP-like immunoreactivity is concentrated in hypothalamic neurosecretory nuclei, suggesting an unidentified related peptide may exist (Kovalzon 2006).
In rats, DSIP was reported to modulate pineal N-acetyltransferase, an enzyme in melatonin synthesis, with involvement of alpha1-adrenergic receptors.
The peptide is subject to degradation in plasma and serum, which complicates interpretation of studies with systemic exposure.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
1977
Rabbit study
PMID 265572Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.
Schoenenberger GA, Monnier M. · Proc Natl Acad Sci U S A
Of nine synthetic peptides infused intraventricularly into rabbits under double-blind conditions (58 animals including controls), only DSIP produced significant, specific enhancement of delta and spindle EEG patterns.
1992
Small RCT
PMID 1299794Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.
Bes F, et al. · Neuropsychobiology
In 16 chronic insomniac patients, DSIP was associated with higher sleep efficiency and shorter sleep latency than placebo, but effects were weak and partly reflected placebo-group changes; authors judged a major therapeutic effect unlikely.
2006
Review
PMID 16539679Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
Kovalzon VM, Strekalova TV. · J Neurochem
Concludes that the role of DSIP as a sleep factor remains poorly documented because no gene, protein precursor, or receptor has been isolated, and proposes that a related DSIP-like peptide underlies observed activity.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
Human evidence consists of small, mostly older studies with inconsistent results, and the double-blind insomnia trial found only weak effects. No gene, precursor, or receptor has been identified, adverse-event data are sparse, and DSIP is not approved by the FDA or EMA.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| DS5 | DSIP | 5mg*10vials | 10 |
| DS10 | DSIP | 10mg*10vials | 10 |
| DS15 | DSIP | 15mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.