Semax + Selank
A combination of Semax, an ACTH(4-10)-derived peptide, and Selank, a tuftsin-derived peptide. Each component has its own literature; no indexed study has tested the two as a combined preparation.
Research blend
Size
2 options- Catalog no.
- XS10
- Specification
- 10ml*10vials
- Per kit
- 10 vials
Composition as listed: Semax5 + Selank5
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
This blend pairs two heptapeptides developed in Russia that share a C-terminal Pro-Gly-Pro motif. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is studied mainly for neurotrophin signaling and ischemic brain injury. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is studied mainly for anxiolytic-like and immunomodulatory activity. Several papers have examined both peptides side by side, in separate treatment groups, in enzyme assays, rodent behavior, and human brain imaging. No indexed study has tested them as a combined preparation, so interactions, additive effects, and the pharmacology of a blend are unknown.
Class: Blend of two synthetic regulatory heptapeptides
Mechanism of action
How the compound acts, as described in the literature.
Semax: in rats, raised hippocampal BDNF and trkB expression and trkB phosphorylation, and altered immune- and vascular-related gene expression after focal cerebral ischemia.
Selank: inhibits enkephalin-degrading enzymes in plasma in vitro and altered GABAergic neurotransmission gene expression in rat frontal cortex.
In a single in vitro study, both peptides inhibited enkephalin-degrading enzymes from human serum, with Semax somewhat more potent than Selank.
No study has examined pharmacokinetic or pharmacodynamic interactions between the two peptides.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2020
Placebo-controlled human fMRI study
PMID 32342318Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova YR, et al. · Dokl Biol Sci
In 52 healthy participants given Semax, Selank, or placebo, resting-state fMRI showed general and peptide-specific changes in connectivity between the right amygdala and right temporal cortex. The peptides were given separately.
2017
Rodent study
PMID 28702721Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.
Slominsky PA, et al. · Dokl Biol Sci
In rats with 6-OHDA-induced dopaminergic lesions, neither peptide changed motor activity, while Selank reduced anxiety-like behavior in the elevated plus maze. Each peptide was tested separately.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
The combination has never been studied, so interactions, combined effects, and safety are unknown; the studies listed tested each peptide separately. Evidence for each component is mostly small-sample work from Russian groups, and neither peptide is approved by the FDA or EMA.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| XS10 | Semax5 + Selank5 | 10ml*10vials | 10 |
| XS20 | Semax10 + Selank10 | 20ml*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.