SLU-PP-332
SLU-PP-332 is a synthetic small molecule that activates the estrogen-related receptors ERRα, ERRβ, and ERRγ. It has been studied in mice as an exercise mimetic that increases oxidative metabolism.
Preclinical research
Size
2 options- Catalog no.
- SLK5
- Specification
- 5mg*10vials
- Per kit
- 10 vials
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
SLU-PP-332 is a synthetic small molecule, not a peptide; the SLU prefix refers to Saint Louis University, where the compound series originated. It targets the estrogen-related receptors (ERRs), nuclear receptors that do not bind estrogen despite their name. ERRs regulate genes for mitochondrial biogenesis, fatty acid oxidation, and oxidative muscle fibers, a program also switched on by endurance exercise. SLU-PP-332 activates all three ERR isoforms, with highest potency at ERRα. Published research consists of cell and mouse studies of exercise capacity, metabolic syndrome, heart failure, and kidney aging.
Class: Synthetic pan-estrogen-related receptor (ERRα/β/γ) agonist
Mechanism of action
How the compound acts, as described in the literature.
Acts as an agonist at ERRα, ERRβ, and ERRγ, with highest potency at ERRα. ERRs are constitutively active nuclear receptors that work with the coactivator PGC-1α to drive oxidative metabolism genes.
In muscle cells it increased mitochondrial function and respiration. In mice it increased type IIa oxidative fibers and induced an acute aerobic exercise gene program that depended on ERRα.
In obese mouse models it increased energy expenditure and fatty acid oxidation, decreased fat mass accumulation, and improved insulin sensitivity.
In aged mice it reversed kidney mitochondrial dysfunction and inflammation, with effects involving cGAS-STING and STAT3 signaling.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2023
Rodent and in vitro study
PMID 36988910Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.
Billon C, et al. · ACS Chem Biol
SLU-PP-332 increased mitochondrial respiration in a skeletal muscle cell line. In mice it increased oxidative type IIa fibers and exercise endurance, effects linked to an ERRα-dependent aerobic exercise gene program.
2024
Rodent study
PMID 37739806A Synthetic ERR Agonist Alleviates Metabolic Syndrome.
Billon C, et al. · J Pharmacol Exp Ther
In diet-induced obese and ob/ob mice, the pan-ERR agonist increased energy expenditure and fatty acid oxidation, decreased fat mass accumulation, and improved insulin sensitivity.
2023
Rodent study
PMID 37717940Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.
Wang XX, et al. · Am J Pathol
ERR levels were reduced in aging human and mouse kidneys. In 21-month-old mice, eight weeks of SLU-PP-332 reversed albuminuria, podocyte loss, mitochondrial dysfunction, and increases in inflammatory cytokines.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
All published evidence comes from cell and mouse studies; no human studies or formal toxicology reports are indexed on PubMed. The core exercise and metabolic studies come from one research group, and several authors declared stock holdings in Myonid Therapeutics, a company developing ERR-based therapeutics. SLU-PP-332 is not an approved drug.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| SLK5 | SLU-PP-332 | 5mg*10vials | 10 |
| SLK10 | SLU-PP-332 | 10mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.