BPC-157
Also known as Body Protection Compound 157, PL 14736, Bepecin
BPC-157 is a synthetic 15-amino-acid peptide derived from a protein found in human gastric juice. It is studied mainly in rodent models of tendon, muscle, gastrointestinal and vascular injury.
Preclinical research
Size
4 options- Catalog no.
- BC5
- Specification
- 5mg*10vials
- Per kit
- 10 vials
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
BPC-157 (Body Protection Compound 157) was described in the early 1990s by Predrag Sikirić's group at the University of Zagreb as a partial sequence of a larger gastric juice protein. Its sequence is GEPPPGKPADDAGLV, and the originating group reports that it is stable in gastric juice. Most published work is rodent research on gastrointestinal lesions, tendon and ligament transection, muscle injury and vascular occlusion, much of it from that same group. Human data are limited to three small uncontrolled studies. BPC-157 is not an approved drug, and the World Anti-Doping Agency lists it as a prohibited substance.
Class: Synthetic gastric pentadecapeptide
Mechanism of action
How the compound acts, as described in the literature.
In rat tendon explants and fibroblasts, BPC-157 accelerated outgrowth and increased cell survival under oxidative stress and cell migration, with greater FAK and paxillin phosphorylation, without changing proliferation.
In endothelial cells and a rat hind-limb ischemia model, it increased VEGFR2 expression and internalization and activated VEGFR2–Akt–eNOS signaling, alongside higher vessel density and faster blood-flow recovery.
Rodent studies from the originating group report that it modulates the nitric oxide system, counteracting effects of both the NOS inhibitor L-NAME and the NO precursor L-arginine in several models.
In cultured tendocytes, it reversed growth inhibition caused by the lipid peroxidation product 4-hydroxynonenal.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2003
Rodent study
PMID 14554208Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.
Staresinic M, et al. · J Orthop Res
In rats with transected Achilles tendons, BPC-157 improved biomechanical strength, functional recovery and histological healing versus saline controls, and reversed 4-hydroxynonenal-induced growth inhibition of cultured tendocytes.
2017
Rodent and in vitro study
PMID 27847966Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.
Hsieh MJ, et al. · J Mol Med (Berl)
BPC-157 increased vessel density in chick embryo membrane assays, accelerated blood-flow recovery after rat hind-limb ischemia, and raised VEGFR2 expression and VEGFR2–Akt–eNOS signaling in endothelial cells; dynasore blocked these effects.
2026
Systematic review
PMID 42885452Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety.
Poolton JT, et al. · Acta Orthop Belg
Three small human studies (30 participants: knee pain, interstitial cystitis, and a two-person safety pilot) reported symptom improvement without drug-related adverse events, but all were judged poor quality and overall certainty was very low.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
Nearly all evidence comes from rodent and cell studies, much of it from a single research group, and independent replication is limited. A 2026 systematic review found only three small uncontrolled human studies, rated very low certainty; no drug-related adverse events were reported, but human safety has not been established. Reviews also raise a theoretical concern that its pro-angiogenic activity could support tumor growth; BPC-157 is unapproved and prohibited in sport by WADA.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| BC5 | BPC-157 | 5mg*10vials | 10 |
| BC10 | BPC-157 | 10mg*10vials | 10 |
| BC15 | BPC-157 | 15mg*10vials | 10 |
| BC20 | BPC-157 | 20mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.