BPC-157 + TB-500
A combination of BPC-157, a synthetic gastric pentadecapeptide, and TB-500 (thymosin beta-4). Both components have been studied individually in tissue-repair models; research on the combination is limited to a single rodent study.
Research blend
Size
2 options- Catalog no.
- BB10
- Specification
- 10mg*10vials
- Per kit
- 10 vials
Composition as listed: BPC 5mg + TB 5mg
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
This product pairs two peptides that are usually studied separately. BPC-157 is a 15-amino-acid fragment of a gastric juice protein, studied mostly in rodent models of tendon, gut and vascular injury. TB-500 is a trade name for synthetic thymosin beta-4, a 43-amino-acid actin-binding peptide studied in wound, cardiac and corneal repair; the name has also been applied to a short Tβ4 fragment. The rationale for combining them rests on their separate preclinical profiles. A 2026 rat Achilles tendon study compared each peptide with the pairing and found no added effect from the combination. No human studies of the combination are indexed.
Class: Two-peptide combination (BPC-157 and thymosin beta-4)
Mechanism of action
How the compound acts, as described in the literature.
BPC-157: in rodent and cell studies, associated with tendon fibroblast migration and survival through FAK–paxillin signaling, and with VEGFR2–Akt–eNOS activation and new vessel formation.
Thymosin beta-4: sequesters monomeric actin, regulating cytoskeletal remodeling during cell migration; it has been linked to keratinocyte migration, angiogenesis and ILK–Akt survival signaling in cardiac cells.
Proposed rationale: the two peptides act on different pathways (receptor and adhesion signaling versus actin dynamics), but additive or synergistic effects have not been demonstrated.
In the one direct comparison, in rats, the combined group did not outperform either peptide alone; the authors suggested convergence on shared downstream pathways, which remains unconfirmed.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2026
Rodent study
PMID 42542926Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
Biçer O, et al. · Jt Dis Relat Surg
In 32 rats with repaired Achilles tendon transections, TB-500 alone significantly increased load to failure and improved histology scores; BPC-157 changes were mostly nonsignificant, and the combination showed no advantage over either single agent.
2003
Rodent study
PMID 14554208Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.
Staresinic M, et al. · J Orthop Res
BPC-157 alone: in rats with transected Achilles tendons, it improved biomechanical, functional and histological measures of healing versus saline, and stimulated growth of cultured tendocytes.
1999
Rodent study
PMID 10469335Thymosin beta4 accelerates wound healing.
Malinda KM, et al. · J Invest Dermatol
Thymosin beta-4 alone: in rat full-thickness skin wounds, it increased re-epithelialization, wound contraction, collagen deposition and angiogenesis versus saline, and stimulated keratinocyte migration in vitro.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
The combination has been studied only once, in a 32-rat tendon study that found no advantage over either peptide alone, and there are no human data on the pairing. Evidence for each component is mainly preclinical, and elevated thymosin beta-4 expression has been linked to tumor cell migration in colorectal cancer studies. Neither peptide is an approved drug, and both are prohibited in sport by WADA.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| BB10 | BPC 5mg + TB 5mg | 10mg*10vials | 10 |
| BB20 | BPC 10mg + TB 10mg | 10mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.