KLOW
KLOW is a vendor name for a combination of BPC-157, GHK-Cu, TB-500 (thymosin beta-4) and the anti-inflammatory tripeptide KPV. The components have been studied separately; the four-peptide combination has not been studied.
Research blend
Size
1 option- Catalog no.
- Klow
- Specification
- 80mg*10vials
- Per kit
- 10 vials
Composition as listed: BPC 157 10mg + GHK-CU 50mg + TB500 10mg + KPV 10mg
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
KLOW adds KPV to the three-peptide combination of BPC-157, GHK-Cu and TB-500. BPC-157 is a gastric peptide fragment studied in rodent injury models; GHK-Cu is a copper-binding tripeptide studied for effects on fibroblasts and collagen; TB-500 is a trade name for synthetic thymosin beta-4, an actin-binding peptide studied in tissue repair. KPV (lysine-proline-valine) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone and has been studied in mouse models of colitis. No study of the four-peptide combination is indexed on PubMed; only the BPC-157 and TB-500 pairing has been compared directly, in one rat study.
Class: Four-peptide combination (BPC-157, GHK-Cu, thymosin beta-4, KPV)
Mechanism of action
How the compound acts, as described in the literature.
BPC-157: associated in rodent and cell studies with FAK–paxillin signaling in tendon fibroblasts and with VEGFR2–Akt–eNOS activation linked to angiogenesis.
GHK-Cu: a copper(II)-binding tripeptide that stimulated collagen synthesis in fibroblast cultures and has been studied for effects on extracellular matrix remodeling.
Thymosin beta-4: sequesters monomeric actin, regulating cell migration, and has been linked to ILK–Akt survival signaling and angiogenesis in preclinical models.
KPV: taken up by intestinal epithelial and immune cells through the PepT1 transporter, where it reduced NF-κB and MAP kinase inflammatory signaling; its effects appear partly independent of the melanocortin-1 receptor.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
2026
Rodent study
PMID 42542926Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
Biçer O, et al. · Jt Dis Relat Surg
Covers two of the four components: in rats with repaired Achilles tendons, TB-500 alone improved load to failure and histology scores, and BPC-157 plus TB-500 showed no advantage over either alone. GHK-Cu and KPV were not tested.
1988
In vitro
PMID 3169264Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.
Maquart FX, et al. · FEBS Lett
GHK-Cu alone: in fibroblast cultures, the tripeptide-copper complex stimulated collagen synthesis beginning at about 10⁻¹² to 10⁻¹¹ M and peaking near 10⁻⁹ M, without a change in cell number.
2008
In vitro and mouse study
PMID 18061177PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Dalmasso G, et al. · Gastroenterology
KPV alone: in intestinal epithelial and T-cell lines, nanomolar KPV reduced cytokine-induced NF-κB and MAP kinase signaling and cytokine secretion via PepT1 uptake; oral KPV reduced DSS- and TNBS-induced colitis in mice.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
The four-peptide combination has never been studied; combination data are limited to one rat study of BPC-157 plus TB-500, which found no advantage over either alone. KPV has no human data, human data for the other components are limited, and elevated thymosin beta-4 expression has been linked to tumor cell migration in colorectal cancer studies. None of the components is an approved drug, and BPC-157 and TB-500 are prohibited in sport by WADA.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| Klow | BPC 157 10mg + GHK-CU 50mg + TB500 10mg + KPV 10mg | 80mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.