GHRP-6 Acetate
Also known as Growth hormone-releasing hexapeptide
One of the first synthetic growth hormone-releasing peptides, a hexapeptide whose study led to the identification of the ghrelin receptor.
Preclinical research
Size
2 options- Catalog no.
- G65
- Specification
- 5mg*10vials
- Per kit
- 10 vials
For laboratory research use only. Not for human or animal consumption. Buyers must be 21 or older.
Overview
GHRP-6 is a synthetic hexapeptide first described in 1984 as a specific pituitary GH-releasing agent. Its unusual activity, distinct from GHRH, led researchers to search for its receptor. That receptor, the growth hormone secretagogue receptor, was cloned in 1996, and its natural ligand, ghrelin, was found in 1999. GHRP-6 remains a reference compound in ghrelin receptor research and is known for a strong effect on appetite. It was never developed into an approved medicine.
Class: Ghrelin receptor (GHS-R1a) agonist
Mechanism of action
How the compound acts, as described in the literature.
Agonist at the growth hormone secretagogue receptor (GHS-R1a), later identified as the ghrelin receptor.
Stimulates GH release from the pituitary and amplifies the GH response to GHRH.
Strongly stimulates appetite through hypothalamic ghrelin receptor signaling.
Can raise ACTH, cortisol and prolactin, reflecting broader receptor effects than more selective agents.
Published research
Selected studies, each linked to its PubMed record. Summaries describe what the studies reported.
1984
In vitro and animal study
PMID 6714155On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone.
Bowers CY, et al. · Endocrinology
Described a synthetic hexapeptide that specifically released growth hormone from the pituitary in vitro and in vivo, establishing the GHRP class.
1996
Molecular study
PMID 8688086A receptor in pituitary and hypothalamus that functions in growth hormone release.
Howard AD, et al. · Science
Cloned the G protein-coupled receptor in pituitary and hypothalamus through which GH secretagogues such as GHRP-6 act, later named the ghrelin receptor.
Evidence & safety
What the research does not show, and the adverse events and regulatory status it reports.
Evidence is largely animal work and early human pharmacology; it was never developed as a medicine. It strongly stimulates appetite and can raise cortisol and prolactin. No long-term human safety data exist.
Specifications
All sizes, exactly as catalogued.
| Catalog no. | Product | Specification | Vials per kit |
|---|---|---|---|
| G65 | GHRP-6 Acetate | 5mg*10vials | 10 |
| G610 | GHRP-6 Acetate | 10mg*10vials | 10 |
For laboratory research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease. Research summaries are provided for educational purposes and do not describe this product’s use.